IAVI Discovery 500pxIAVI’s vaccine discovery and development laboratories are focused on critical questions of how to generate protective immune responses against HIV. Photo credit: Joy Glenn Photography

IAVI’s vaccine discovery and development laboratories are focused on identifying ways to generate protective immune responses against HIV, characterizing and optimizing antibodies as prevention products, and addressing other unmet global health needs.

IAVI collaborates closely with other innovators across the HIV research landscape and focuses its own research on the areas most likely to make important inroads in our understanding of how to defeat HIV.

In 2008, IAVI established the Vaccine Design and Development Laboratory (DDL) to facilitate the design and development of viral vectors for vaccines. Scientists at the DDL engineer natural viruses to deliver vaccine immunogens with the goal of generating long-lasting antiviral immune responses. The DDL team develops vectors based on vesicular stomatitis virus (VSV) for both HIV and Lassa fever.

Since 2009, due to the efforts of the IAVI Neutralizing Antibody Center (NAC) at Scripps Research and other institutions, hundreds of broadly neutralizing antibodies (bNAbs) have been isolated from HIV-infected volunteers. The structures of some of the most potent of these antibodies and their targets on the virus have also been solved. These discoveries are now informing the design of novel HIV vaccine candidates.

The HIV Vaccine Translational Research (HVTR) Laboratory at the Translational Health Science and Technology Institute (THSTI) NCR Biotech Science Cluster in Faridabad, Haryana, India, designs and evaluates preventive HIV vaccines. As a NAC-collaborating center of excellence, the laboratory plays a crucial role in spurring indigenous antibody discovery and preclinical development efforts and promoting industry collaboration on promising prevention products. 

The IAVI Human Immunology Laboratory (HIL), based at Imperial College London, serves as the clinical immunology reference laboratory for IAVI and its research partners worldwide. The HIL specializes in the analysis of immune responses from studies and clinical trials by IAVI and its partners, and serves as a central repository for samples collected from clinical and epidemiology research studies.