IAVI Discovery 500pxIAVI’s vaccine discovery and development laboratories are focused on critical questions of how to generate protective immune responses against HIV. Photo credit: Joy Glenn Photography

IAVI’s vaccine discovery and development laboratories are focused on identifying ways to generate protective immune responses against HIV and other infectious diseases, characterizing and optimizing antibodies as prevention and treatment products, and addressing other unmet global health needs. In doing this wide-ranging work, IAVI researchers collaborate closely with other innovators across the global health research landscape.

In 2008, IAVI established the Vaccine Design and Development Laboratory (DDL) to facilitate the design and development of viral vectors for vaccines. Scientists at the DDL engineer natural viruses to deliver vaccine immunogens with the goal of generating long-lasting antiviral immune responses. The DDL team uses the vesicular stomatitis virus (VSV) as a vector to develop vaccine candidates for HIV and emerging infectious diseases such as Lassa fever, Marburg virus diseases, Sudan ebolavirus, and COVID-19.

Since 2009, due to the efforts of the IAVI Neutralizing Antibody Center (NAC) at Scripps Research and other institutions, hundreds of broadly neutralizing antibodies (bnAbs) have been isolated from volunteers with HIV. The structures of some of the most potent of these antibodies and their targets on the virus have also been solved. NAC scientists are now using these discoveries to inform the design of novel HIV vaccine candidates and are using advances in antibody science to develop antibodies to prevent and treat other diseases.

The HIV Vaccine Translational Research (HVTR) Laboratory at the Translational Health Science and Technology Institute (THSTI) NCR Biotech Science Cluster in Faridabad, Haryana, India, designs and evaluates preventive HIV vaccines. As a NAC-collaborating center of excellence, the laboratory plays a crucial role in spurring indigenous antibody discovery and preclinical development efforts and promoting industry collaboration on promising prevention products.

The IAVI Human Immunology Laboratory (HIL), based at Imperial College London, serves as the clinical immunology reference laboratory for IAVI and its research partners worldwide. The HIL specializes in the analysis of immune responses from studies and clinical trials by IAVI and its partners, serves as a central repository for samples collected from clinical and epidemiology research studies, and plays a crucial role in strengthening existing scientific capabilities in affiliated African and Indian laboratories.