Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

Affiliations

• ¹ Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, International AIDS Vaccine Initiative, New York, NY 10038;
• ² Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
• ³ Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery.
• ⁴ International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Department of Integrative Structural and Computational Biology, and Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute and Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario, M5G 0A4 Canada;
• ⁵ International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Department of Integrative Structural and Computational Biology, and.
• ⁶ Department of Integrative Structural and Computational Biology, and.
• ⁷ Beth Israel Deaconess Medical Center, Boston, MA 02215;
• ⁸ Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021; and.
• ⁹ International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Department of Integrative Structural and Computational Biology, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037;
• ¹⁰ Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021; and rws2002@med.cornell.edu burton@scripps.edu.
• ¹¹ Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02142 rws2002@med.cornell.edu burton@scripps.edu.