PMID: 30333615
Title: Recent progress in broadly neutralizing antibodies to HIV
Abstract: In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.
Date: 1970-08-22
Year: 2018
Journal: Nat. Immunol.
PMID Author: Sok D, Burton DR
IAVI Topics: HIV Neutralizing Antibodies

Recent progress in broadly neutralizing antibodies to HIV. Nat. Immunol. 2018;19(11):1179-1188 doi: 10.1038/s41590-018-0235-7

Media Contacts

Africa

Ethel Makila
+254 71 904 3142
EMakila@iavi.org

 

Europe

Hester Kuipers
+31 20 521 0343
HKuipers@iavi.org 

 

India

Saif ul Hadi
+91 11 4737 6032
SulHadi@iavi.org 

 

United States

Rose Catlos
+1 212 847 1049
RCatlos@iavi.org