PMID: 20299194
Title: Rational antibody based HIV 1 vaccine design current approaches and future directions
Abstract: Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.
Date: 1970-08-21
Year: 2010
Journal: Curr. Opin. Immunol.
PMID Author: Walker LM, Burton DR
PMC Link #: PMC2891291
Rational antibody-based HIV-1 vaccine design: current approaches and future directions. Curr. Opin. Immunol. 2010;22(3):358-66 doi: 10.1016/j.coi.2010.02.012

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