Optimizing parallel induction of HIV type 1 specific antibody and T cell responses by multicomponent subunit vaccines
Protection against HIV type 1 (HIV-1) infection/AIDS will likely require concerted actions of protective CD8(+) killer T cells and protective antibodies. The challenges in inducing such effectors by active immunization are such that the T-cell and antibody vaccine components require separate development. Here, a rational attempt is taken to combine two separately optimized heterologous regimens into a single T-cell-inducing and antibody-inducing vaccination schedule with minimal induction of unprotective Env-specific T cells.
- PMID Author:
Clutton G, Carpov A, Parks CL, Dean HJ, Montefiori DC, Hanke T