Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection

Virology. 2014 Aug:462-463:295-8. doi: 10.1016/j.virol.2014.06.016. Epub 2014 Jul 5.

Abstract

We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies.

Keywords: ADCC; HIV dual infection; HIV-1 ADCC; HIV-1 superinfection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV Antibodies / immunology*
  • HIV Infections / immunology*
  • HIV Infections / virology*
  • HIV-1 / immunology*
  • Humans
  • Immunity, Cellular*
  • Superinfection / immunology*

Substances

  • HIV Antibodies