PMID: 28914669
Title: Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno Assay Platforms
Abstract: Custom HIV staging assays, including the Sedia HIV-1 Limiting Antigen (LAg) Avidity EIA and avidity modifications of the Ortho VITROS anti-HIV-1+2 and Abbott ARCHITECT HIV Ag/Ab Combo assays, are used to identify 'recent' infections in clinical settings and for cross-sectional HIV incidence estimation. However, the high dynamic range of chemiluminescent platforms allows differentiating recent and long-standing infection on signal intensity, and this raises the prospect of using unmodified diagnostic assays for infection timing and surveillance applications.
Date: 1970-08-22
Year: 2017
Journal: J. Acquir. Immune Defic. Syndr.
PMID Author: Grebe E, Welte A, Hall J, Keating SM, Facente SN, Marson K, Martin JN, Little SJ, Price MA, Kallas EG, Busch MP, Pilcher CD, Murphy G
PMC Link #: NIHMS902523
Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno-Assay Platforms. J. Acquir. Immune Defic. Syndr. 2017;76(5):547-555 doi: 10.1097/QAI.0000000000001537

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