Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

Affiliations

• ¹ Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
• ² Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
• ³ Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
• ⁴ Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
• ⁵ Department of Chemistry, University of Kansas, Lawrence, KS 66047, USA.
• ⁶ Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
• ⁷ Microbial Systems Ecology, Department of Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam 1098 XH, the Netherlands.
• ⁸ Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
• ⁹ Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
• ¹⁰ Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address: rws2002@med.cornell.edu.