Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base
The HIV-1 env oligomer is structured such that conserved, neutralizing epitopes are obscured by gp120 variable loops. We have studied the ability of an IgG2 human monoclonal antibody (hmAb), F425 B4e8 (B4e8), dependent upon the base of the V3 loop, to induce conformational changes in the env oligomer.
- PMID Author:
Cavacini L, Duval M, Song L, Sangster R, Xiang SH, Sodroski J, Posner M