PMID: 18593118
Title: Allyl sulfides are privileged substrates in aqueous cross metathesis application to site selective protein modification
Abstract: Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second generation catalyst 1. The high reactivity of allyl sulfides in cross-metathesis was exploited in the first examples of cross-metathesis on a protein surface. S-Allylcysteine was incorporated chemically into the protein, providing the requisite allyl sulfide handle. Preliminary efforts to genetically incorporate S-allylcysteine into proteins are also reported.
Date: 1970-08-21
Year: 2008
Journal: J. Am. Chem. Soc.
PMID Author: Lin YA, Chalker JM, Floyd N, Bernardes GJ, Davis BG

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