Scientific Publications
- PMID: 21399681
- Title: Viral linkage in HIV 1 seroconverters and their partners in an HIV 1 prevention clinical trial
- Abstract: Characterization of viruses in HIV-1 transmission pairs will help identify biological determinants of infectiousness and evaluate candidate interventions to reduce transmission. Although HIV-1 sequencing is frequently used to substantiate linkage between newly HIV-1 infected individuals and their sexual partners in epidemiologic and forensic studies, viral sequencing is seldom applied in HIV-1 prevention trials. The Partners in Prevention HSV/HIV Transmission Study (ClinicalTrials.gov #NCT00194519) was a prospective randomized placebo-controlled trial that enrolled serodiscordant heterosexual couples to determine the efficacy of genital herpes suppression in reducing HIV-1 transmission; as part of the study analysis, HIV-1 sequences were examined for genetic linkage between seroconverters and their enrolled partners.
- Date: 1970-08-21
- Year: 2011
- Journal: PLoS ONE
- PMID Author: Campbell MS, Mullins JI, Hughes JP, Celum C, Wong KG, Raugi DN, Sorensen S, Stoddard JN, Zhao H, Deng W, Kahle E, Panteleeff D, Baeten JM, McCutchan FE, Albert J, Leitner T, Wald A, Corey L, Lingappa JR
Viral linkage in HIV 1 seroconverters and their partners in an HIV 1 prevention clinical trial
Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial. PLoS ONE 2011;6(3):e16986 doi: 10.1371/journal.pone.0016986
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