Vaccination with SIVmac239Deltanef activates CD4 T cells in the absence of CD4 T cell loss
Pathogenic HIV and SIV infections characteristically deplete central memory CD4(+) T cells and induce chronic immune activation, but it is controversial whether this also occurs after vaccination with attenuated SIVs and whether depletion or activation of CD4(+) T-cell play roles in protection against wild-type virus challenge.
J. Med. Primatol.
- PMID Author:
Reeves RK, Gillis J, Wong FE, Johnson RP
- PMC Link #: