Reagent switchable stereoselective beta 1 2 mannoside mannosylation OH 2 of mannose is a privileged acceptor
The discovery of novel conditions for highly beta-stereoselective (>9 : 1) mannosylation of OH-2 of mannosides using a straightforward perbenzylthioglycoside donor has allowed ready assembly of beta-mannosyl oligosaccharides including the repeating trisaccharide motif of the O5 antigen of pathogen Klebsiella pneumoniae.
Org. Biomol. Chem.
- PMID Author:
Doores KJ, Davis BG