Dual Immunity Concomitantly Suppresses HIV-1 Progression

Huma Qureshi; Jayanta Bhattacharya

doi:10.1016/j.tim.2017.02.011

Dual Immunity Concomitantly Suppresses HIV-1 Progression

Trends Microbiol. 2017 May;25(5):334-335. doi: 10.1016/j.tim.2017.02.011. Epub 2017 Mar 8.

Authors

Huma Qureshi¹, Jayanta Bhattacharya²

Affiliations

¹ Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Department of Biotechnology, Faridabad, Haryana 121001, India.
² Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Department of Biotechnology, Faridabad, Haryana 121001, India; International AIDS Vaccine Initiative, New York, NY, USA. Electronic address: JBhattacharya@thsti.res.in.

PMID: 28284876
DOI: 10.1016/j.tim.2017.02.011

Abstract

Broadly neutralizing antibodies (bnAbs) elicited in HIV-1⁺ elite neutralizers typically are unable to reduce viremia in the same individuals from whom they are isolated. A recent study reports the development of bnAbs in an elite controller that, along with the help of T cells, were associated with restricting HIV-1 progression.

Publication types

Comment

MeSH terms

Acquired Immunodeficiency Syndrome / immunology
Antibodies, Neutralizing / biosynthesis
Antibodies, Neutralizing / immunology*
Disease Progression
HIV Antibodies / immunology*
HIV Infections / immunology*
HIV Infections / physiopathology
HIV-1 / genetics
HIV-1 / immunology*
HIV-1 / physiology
Humans
Viremia / immunology
Virus Replication

Substances

Antibodies, Neutralizing
HIV Antibodies