Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants. Nat Commun 2018;9(1):5023 doi: 10.1038/s41467-018-07209-7
Scientific Publications
- PMID: 30479346
- Title: Dual HLA B 42 and B 81 reactive T cell receptors recognize more diverse HIV 1 Gag escape variants
- Abstract: Some closely related human leukocyte antigen (HLA) alleles are associated with variable clinical outcomes following HIV-1 infection despite presenting the same viral epitopes. Mechanisms underlying these differences remain unclear but may be due to intrinsic characteristics of the HLA alleles or responding T cell repertoires. Here we examine CD8 T cell responses against the immunodominant HIV-1 Gag epitope TL9 (TPQDLNTML) in the context of the protective allele B*81:01 and the less protective allele B*42:01. We observe a population of dual-reactive T cells that recognize TL9 presented by both B*81:01 and B*42:01 in individuals lacking one allele. The presence of dual-reactive T cells is associated with lower plasma viremia, suggesting a clinical benefit. In B*42:01 expressing individuals, the dual-reactive phenotype defines public T cell receptor (TCR) clones that recognize a wider range of TL9 escape variants, consistent with enhanced control of viral infection through containment of HIV-1 sequence adaptation.
- Date: 1970-08-21
- Year: 2018
- Journal: Nat Commun
- PMID Author: Ogunshola F, Anmole G, Miller RL, Goering E, Nkosi T, Muema D, Mann J, Ismail N, Chopera D, Ndung'u T, Brockman MA, Ndhlovu ZM
- PMC Link #: PMC6258674
- IAVI Topics: HLA
Dual HLA B 42 and B 81 reactive T cell receptors recognize more diverse HIV 1 Gag escape variants
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