Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection
Detailed genetic and structural characterization has revealed that broadly neutralizing antibodies (bnAbs) against HIV-1 have unusually high levels of somatic hypermutation, long CDRH3 domains, and the ability to target one of four sites of vulnerability on the HIV-1 envelope (Env) glycoproteins. A current priority is to understand how bnAbs are generated during natural infection, and translate this information into immunogens that can elicit bnAb following vaccination.
Curr Opin HIV AIDS
- PMID Author:
Derdeyn CA, Moore PL, Morris L
- PMC Link #: