Scientific Publications
- PMID: 18593118
- Title: Allyl sulfides are privileged substrates in aqueous cross metathesis application to site selective protein modification
- Abstract: Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second generation catalyst 1. The high reactivity of allyl sulfides in cross-metathesis was exploited in the first examples of cross-metathesis on a protein surface. S-Allylcysteine was incorporated chemically into the protein, providing the requisite allyl sulfide handle. Preliminary efforts to genetically incorporate S-allylcysteine into proteins are also reported.
- Date: 1970-08-21
- Year: 2008
- Journal: J. Am. Chem. Soc.
- PMID Author: Lin YA, Chalker JM, Floyd N, Bernardes GJ, Davis BG
Allyl sulfides are privileged substrates in aqueous cross metathesis application to site selective protein modification
Media Contacts
North America
Rose Catlos
+1 212 847 1049
RCatlos@iavi.org