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Database of Preventative HIV Vaccine Candidates

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Phase Trial ID Status Prime Boost1 Boost2 Boost3 Strategy Location
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IIb HVTN 704 AMP Ongoing VRC-HIVMAB060-00-AB Passive Immunization USA, Peru, Brazil
I 01-I-0079 Completed VRC4302 DNA USA
I 04/400-003-04 Completed APL 400-003 GENEVAX-HIV DNA USA
I 10-1074 Ongoing 10-1074 Passive Immunization Germany, USA
I 87 I-114 Completed gp160 Vaccine (Immuno-AG) Protein USA
I 96-I-0050 Completed APL 400-003 GENEVAX-HIV DNA USA
I/II ACTG 326; PACTG 326 Completed ALVAC vCP1452 AIDSVAX B/B Viral Vector - Pox, Protein USA
I Ad26.ENVA.01 Completed Ad26.EnvA-01 Viral Vector - Adeno USA
I Ad26.ENVA.01 Mucosal/IPCAVD003 Ongoing Ad26.EnvA-01 Viral Vector - Adeno USA
I Ad5HVR48.ENVA.01 Ongoing Ad5HVR48.ENVA.01 Viral Vector - Adeno USA
I APL 400-003RX101 Completed APL 400-003 GENEVAX-HIV DNA USA
I AVEG 002 Completed HIVAC-1e gp160 MN/LAI Viral Vector - Pox, Protein USA
I AVEG 002A Completed HIVAC-1e Viral Vector - Pox USA
I AVEG 002B Completed HIVAC-1e VaxSyn gp160 Vaccine (MicroGeneSys) Viral Vector - Pox, Protein USA
I AVEG 003 Completed VaxSyn gp160 Vaccine (MicroGeneSys) Protein USA
I AVEG 003A Completed VaxSyn gp160 Vaccine (MicroGeneSys) Protein USA
I AVEG 003B Completed VaxSyn gp160 Vaccine (MicroGeneSys) Protein USA
I AVEG 004 Completed gp160 Vaccine (Immuno-AG) Protein USA
I AVEG 004A Completed gp160 Vaccine (Immuno-AG) Protein USA
I AVEG 004B Completed gp160 Vaccine (Immuno-AG) Protein USA
I AVEG 005A/B Completed Env 2-3 Protein USA
I AVEG 005C Completed Env 2-3 Protein USA
I AVEG 006X; VEU 006 Completed MN rgp120 Protein USA
I AVEG 007A/B Completed rgp120/HIV-1 SF-2 Protein USA
I AVEG 007C Completed rgp120/HIV-1 SF-2 Protein USA
I AVEG 008 Completed HIVAC-1e Viral Vector - Pox USA
I AVEG 009 Completed MN rgp120 Protein USA
I AVEG 010 Completed HIVAC-1e rgp120/HIV-1 SF-2 MN rgp120 Viral Vector - Pox, Protein, Protein USA
I AVEG 011 Completed UBI HIV-1 Peptide Immunogen, Multivalent Protein USA
I AVEG 012A/B Completed ALVAC vCP125 Viral Vector - Pox USA
I AVEG 013A Completed gp160 Vaccine (Immuno-AG) Protein USA
I AVEG 013B Completed gp160 Vaccine (Immuno-AG) Protein USA
I AVEG 014A/B Completed TBC-3B Viral Vector - Pox USA
I AVEG 014C Completed TBC-3B MN rgp120 Viral Vector - Pox, Protein USA
I AVEG 015 Completed rgp120/HIV-1 SF-2 Protein USA
I AVEG 016 Completed MN rgp120 Protein USA
I AVEG 016A Completed MN rgp120 Protein USA
I AVEG 016B Completed MN rgp120 Protein USA
I AVEG 017 Completed UBI HIV-1 Peptide Vaccine, Microparticulate Monovalent Protein USA
I AVEG 018 Completed UBI HIV-1 Peptide Vaccine, Microparticulate Monovalent Protein USA
I AVEG 019 Completed p17/p24:Ty- VLP Virus Like Particles USA
I AVEG 020 Completed gp120 C4-V3 Protein USA
I AVEG 021 Completed P3C541b Lipopeptide Protein USA
I AVEG 022 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
I AVEG 022A Completed ALVAC-HIV MN120TMG strain (vCP205) rgp120/HIV-1 SF-2 Viral Vector - Pox, Protein USA
I AVEG 023 Completed UBI HIV-1 Peptide Immunogen, Multivalent Protein USA
I AVEG 024 Completed rgp120/HIV-1 SF-2 Protein USA
I AVEG 026 Completed ALVAC vCP300 rgp120/HIV-1 SF-2 Viral Vector - Pox, Protein USA
I AVEG 027 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
I AVEG 028 Completed Salmonella typhi CVD 908-HIV-1 LAI gp 120 MN rgp120 Bacterium + gp 120, Protein USA
I AVEG 029 Completed ALVAC-HIV MN120TMG strain (vCP205) rgp120/HIV-1 SF-2 Viral Vector - Pox, Protein USA
I AVEG 031 Completed APL 400-047 ALVAC-HIV MN120TMG strain (vCP205) DNA, Viral Vector - Pox USA
I AVEG 032 Completed ALVAC-HIV MN120TMG strain (vCP205) rgp120/HIV-1 SF-2 Viral Vector - Pox, Protein USA
I AVEG 033 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
I AVEG 034/034A Completed ALVAC vCP1433 ALVAC vCP1452 ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox, Viral Vector - Pox, Viral Vector - Pox USA
I AVEG 036 Completed MN rgp120 AIDSVAX B/E Protein, Protein USA
I AVEG 038 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
II AVEG 201 Completed rgp120/HIV-1 SF-2 MN rgp120 Protein, Protein USA
II AVEG 202/HIVNET 014 Completed ALVAC-HIV MN120TMG strain (vCP205) rgp120/HIV-1 SF-2 Viral Vector - Pox, Protein USA
I DCVax-001 Completed DCVax-001 Protein USA
I DP6?001 Completed DP6?001 DNA DP6 protein DNA, Protein USA
I DVP-1 Closed to follow-up EnvDNA EnvPro PolyEnv1 DNA, Protein, Viral Vector - Pox USA
I EnvDNA Closed to follow-up EnvDNA DNA USA
I EnvPro Completed EnvPro Protein USA
I Extention HVTN 073E/SAAVI 102 Completed Sub C gp140 Protein South Africa, USA
I HGP-30 memory responses Completed HGP-30 Protein USA
I HVTN 039 Completed ALVAC vCP1452 Viral Vector - Pox USA
I HVTN 040 Completed AVX101 Viral Vector - Alphavirus South Africa, USA
I HVTN 041 Completed rgp120w61d Protein USA
I/II HVTN 042 / ANRS VAC 19 Completed ALVAC vCP1452 LIPO-5 Viral Vector - Pox, Protein USA
I HVTN 044 Completed VRC-HIVDNA009-00-VP DNA USA
I HVTN 045 Completed pGA2/JS7 DNA DNA USA
I HVTN 048 Completed EP HIV-1090 DNA Botswana, USA
I HVTN 049 Completed Gag and Env DNA/PLG microparticles Oligomeric gp140/MF59 DNA, Protein USA
I HVTN 050/Merck 018 Terminated MRKAd5 HIV-1 gag Viral Vector - Adeno Brazil, Dominican Republic, Haiti, Malawi, Peru, South Africa, Thailand, USA
Ib HVTN 052 Completed VRC-HIVDNA009-00-VP DNA USA
I HVTN 054 Completed VRC-HIVADV014-00-VP Viral Vector - Adeno USA
I HVTN 055 Completed TBC-M335 TBC-M358 TBC-F357 Viral Vector - Pox, Viral Vector - Pox, Viral Vector - Pox Brazil, USA
I HVTN 056 Completed MEP Protein USA
I HVTN 057 Completed VRC-HIVDNA009-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I HVTN 059 Completed AVX101 Viral Vector - Alphavirus Botswana, South Africa, USA
I HVTN 060 Completed HIV-1 gag DNA DNA Thailand, USA
I HVTN 063 Completed HIV-1 gag DNA DNA USA
I HVTN 064 Completed EP HIV-1043 EP HIV-1090 Protein, Protein USA
I HVTN 065 Completed pGA2/JS7 DNA MVA/HIV62 DNA, Viral Vector - Pox USA
I HVTN 067 Completed EP-1233 MVA-mBN32 DNA, Viral Vector - Pox USA
IIa HVTN 068 Completed VRC-HIVADV014-00-VP VRC-HIVADV014-00-VP Viral Vector - Adeno, Viral Vector - Adeno USA
Ib HVTN 069 Completed VRC-HIVDNA009-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I HVTN 070 Completed PENNVAX-B DNA USA
Ib HVTN 071 Terminated MRKAd5 HIV-1 gag Viral Vector - Adeno USA
Ib HVTN 072 Completed VRC-HIVDNA044-00-VP VRC-HIVADV027-00-VP VRC-HIVADV038-00-VP DNA, Viral Vector - Adeno, Viral Vector - Adeno USA
I HVTN 073 Completed SAAVI DNA-C2 SAAVI MVA-C DNA, Viral Vector - Pox South Africa, USA
I HVTN 076 Ongoing VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
Ib HVTN 077 Completed VRC-HIVADV027-00-VP VRC-HIVADV038-00-VP VRC-HIVDNA044-00-VP Viral Vector - Adeno, Viral Vector - Adeno, DNA USA
I HVTN 080 Completed PENNVAX-B DNA USA
Ib HVTN 082 Completed VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I HVTN 083 Ongoing VRC-HIVADV038-00-VP VRC-HIVADV052-00-VP VRC-HIVADV027-00-VP Viral Vector - Adeno, Viral Vector - Adeno, Viral Vector - Adeno USA
I HVTN 084 Ongoing VRC-HIVADV054-00-VP VRC-HIVADV014-00-VP Viral Vector - Adeno, Viral Vector - Adeno Peru, Brazil, USA, Swaziland
Ib HVTN 085 Ongoing VRC-HIVADV014-00-VP VRC-HIVADV038-00-VP VRC-HIVADV052-00-VP Viral Vector - Adeno, Viral Vector - Adeno, Viral Vector - Adeno USA, Peru, Brazil, Switzerland
I HVTN 087 Completed HIV-MAG VSV-Indiana HIV gag vaccine DNA, Viral Vector - Replicating USA
I HVTN 088 Completed Oligomeric gp140/MF59 Protein USA
I HVTN 090 Completed VSV-Indiana HIV gag vaccine Viral Vector - Replicating USA
I HVTN 092 Ongoing DNA-HIV-PT123 NYVAC-HIV-PT1 NYVAC-HIV-PT4 DNA, Viral Vector - Pox, Viral Vector - Pox USA, Switzerland
I HVTN 094 Completed GEO-D03 MVA/HIV62 DNA, Viral Vector - Pox USA
I HVTN 098 Ongoing PENNVAX-GP DNA USA
I HVTN 101 Scheduled DNA-HIV-PT123 NYVAC-HIV-PT1 AIDSVAX B/E DNA, Protein USA
I HVTN 104 Completed VRC-HIVMAB060-00-AB Passive Immunization USA
Ib HVTN 105 Completed AIDSVAX B/E DNA-HIV-PT123 Protein, DNA USA
I HVTN 106 Ongoing DNA Nat-B env DNA Mosaic Env MVA-CMDR DNA, DNA, Viral Vector - Pox USA
I/II HVTN 108 Ongoing DNA-HIV-PT123 Bivalent Subtype C gp120/AS01B Bivalent Subtype C gp120/MF59 DNA, Protein, Protein South Africa, USA
I HVTN 110 Ongoing Ad4-mgag Ad4-EnvC150 AIDSVAX B/E Viral Vector - Replicating, Viral Vector - Replicating , Protein USA
I HVTN 112 Ongoing HIV-1 nef/tat/vif, env pDNA vaccine rVSV envC DNA, Viral Vector - Replicating USA
I HVTN 114; GOVX-B11 Scheduled AIDSVAX B/E MVA/HIV62 Protein, Viral Vector - Pox USA
I HVTN 116 Ongoing VRC-HIVMAB060-00-AB VRCHIVMAB080-00-AB Passive Immunization, Passive Immunization South Africa, USA
II HVTN 118 IPCAVD-012 Ongoing Ad26.Mos4.HIV gp140 C Mosaic gp140 Viral Vector - Adeno, Protein, Protein USA, Kenya, Rwanda
II HVTN 203 Completed ALVAC vCP1452 AIDSVAX B/B Viral Vector - Pox, DNA USA
II HVTN 204 Closed to follow-up VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno South Africa, USA
IIa HVTN 205 Completed pGA2/JS7 DNA MVA/HIV62 DNA, Viral Vector - Pox Peru, USA
IIb HVTN 502/Merck 023 (Step Study) Terminated MRKAd5 HIV-1 gag/pol/nef Viral Vector - Adeno Australia, Canada, Dominican Republic, Haiti, Peru, Puerto Rico, USA
IIb HVTN 505 Terminated VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I HVTN 908 Completed pGA2/JS7 DNA MVA/HIV62 DNA, Viral Vector - Pox Peru, USA
I IAVI B001 Completed Ad35-GRIN/ENV Ad35-GRIN/ENV Viral Vector - Adeno, Viral Vector - Adeno USA
I IAVI B003 Completed Ad26.EnvA-01 Ad35-ENV Viral Vector - Adeno, Viral Vector - Adeno Kenya, Rwanda, South Africa, USA
I IAVI C001 Completed ADVAX DNA USA
I IAVI C002 Completed ADMVA Viral Vector - Pox USA
I IAVI C003 Completed ADMVA Viral Vector - Pox USA
I IAVI C004/DHO-614 Completed ADVAX DNA USA
I IAVI R001 Completed rcAd26.MOS1.HIVEnv Viral Vector - Replicating USA
I IAVI T001 Ongoing PGT121 Passive Immunization USA
I IHV01 Ongoing Full-Length Single Chain (FLSC) Protein USA
I IMPAACT P1112 Ongoing VRC-HIVMAB060-00-AB Passive Immunization USA, Puerto Rico, South Africa
I IPCAVD006 Completed MVA mosaic Viral Vector - Pox USA
I IPCAVD008 Completed Trimeric gp140 Protein USA
I/II IPCAVD009 Ongoing Ad26.Mos.HIV Trivalent gp140 C MVA mosaic Viral Vector - Adeno, Protein, Viral Vector - Pox USA, Rwanda, South Africa, Thailand, Uganda
I IPCAVD010 Ongoing Ad26.Mos.HIV Trivalent gp140 C Viral Vector - Adeno, Protein USA
I LFn-p24 vaccine Completed LFn-p24 Protein USA
I MCA-0835 Completed 3BNC117 Passive Immunization Germany, USA
I Merck V520-007 Completed Ad-5 HIV-1 gag (Merck) MRKAd5 HIV-1 gag Viral Vector - Adeno, Viral Vector - Adeno USA
I MRK Ad5 Completed Ad-5 HIV-1 gag (Merck) Viral Vector - Adeno USA
I MRKAd5 + ALVAC Completed MRKAd5 HIV-1 gag ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Adeno, Viral Vector - Pox USA
I PACTG 230 Completed AIDSVAX B/E rgp120/HIV-1 SF-2 Protein, Protein USA
IIb PAVE100 Withdrawn VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I PolyEnv1 Closed to follow-up PolyEnv1 Viral Vector - Pox USA
I PXVX-HIV-100-001 Ongoing Ad4-mgag Ad4-EnvC150 Viral Vector - Replicating, Viral Vector - Replicating USA
I RV 124 Completed ALVAC-HIV MN120TMG strain (vCP205) gp160MN/LAI-2 Viral Vector - Pox, Protein USA
I RV 138; B011 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
I RV 151 / WRAIR 984 Completed LFn-p24 Protein USA
I RV 158 Completed MVA-CMDR Viral Vector - Pox Thailand, USA
I RV 365 Completed MVA-CMDR Viral Vector - Pox USA
I RV262 Completed Pennvax-G MVA-CMDR DNA, Viral Vector - Pox Kenya, Tanzania, Uganda, USA
I TMB-108 Completed Ibalizumab Passive Immunization USA
I/II UBI V106 Completed UBI HIV-1 Peptide Vaccine, Microparticulate Monovalent Protein USA
I UCLA MIG-001 Completed TBC-3B Viral Vector - Pox USA
I UCLA MIG-003 Completed ALVAC-HIV MN120TMG strain (vCP205) Viral Vector - Pox USA
I V24P1 Completed HIV p24/MF59 Vaccine Protein USA
I V3-MAPS Completed V3-MAPS Protein Brazil, China, Australia, Thailand, USA
I V520-016 Completed MRKAd5 HIV-1 gag/pol/nef Viral Vector - Adeno USA
II V520-027 Terminated MRKAd5 HIV-1 gag/pol/nef MRKAd5 HIV-1 gag/pol/nef MRKAd5 HIV-1 gag/pol/nef Viral Vector - Adeno, Viral Vector - Adeno, Viral Vector - Adeno USA
I V526-001 MRKAd5 and MRKAd6 HIV-1 Trigene Vaccines Completed MRKAd5 HIV-1 gag/pol/nef MRKAd6 MRKAd5+6 HIV-1 Viral Vector - Adeno, Viral Vector - Adeno, Viral Vector - Adeno USA
I/II VAX 002 Completed AIDSVAX B/B AIDSVAX B/E Protein, Protein USA
III VAX 004 Completed AIDSVAX B/B Protein Canada, Netherlands, Puerto Rico, USA
I VRC 004 (03-I-0022) Completed VRC-HIVDNA009-00-VP DNA USA
I VRC 006 (04-I-0172) Completed VRC-HIVADV014-00-VP Viral Vector - Adeno USA
I VRC 007 (04-I-0254) Completed VRC-HIVDNA016-00-VP DNA USA
I VRC 008 (05-I-0148) Completed VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I VRC 009 (05-I-0081) Completed VRC-HIVDNA009-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I VRC 010 (05-I-0140) Completed VRC-HIVADV014-00-VP Viral Vector - Pox USA
I VRC 011(06-I-0149) Completed VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I VRC 012 (07-I-0167) Completed VRC-HIVADV027-00-VP VRC-HIVADV038-00-VP Viral Vector - Adeno, Viral Vector - Adeno USA
I VRC 015 (08-I-0171) Completed VRC-HIVADV014-00-VP Viral Vector - Adeno USA
Ib VRC 016 Completed VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno USA
I VRC 602 Completed VRC-HIVMAB060-00-AB Passive Immunization USA
I VRC 605 Ongoing VRC-HIVMAB075-00-AB Passive Immunization USA
I VRC 607 Ongoing VRCHIVMAB080-00-AB Passive Immunization USA
I VRC01LS Ongoing VRCHIVMAB080-00-AB Passive Immunization USA