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Database of Preventative HIV Vaccine Candidates

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Phase Trial ID Status Prime Boost1 Boost2 Boost3 Strategy Location
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I Extention HVTN 073E/SAAVI 102 Completed Sub C gp140 Protein South Africa, USA
I/II HIV-V-A004 Ongoing Ad26.Mos.HIV Trivalent gp140 C MVA mosaic Viral Vector - Adeno, Protein, Viral Vector - Pox USA, Rwanda, South Africa, Thailand, Uganda
II HPTN 076 Ongoing Rilpivirine USA, South Africa
IIa HPTN 077 & ECLAIR Ongoing Cabotegravir Brazil, USA, South Africa, Malawi
I HVTN 040 Completed AVX101 Viral Vector - Alphavirus South Africa, USA
I HVTN 050/Merck 018 Terminated MRKAd5 HIV-1 gag Viral Vector - Adeno Brazil, Dominican Republic, Haiti, Malawi, Peru, South Africa, Thailand, USA
I HVTN 059 Completed AVX101 Viral Vector - Alphavirus Botswana, South Africa, USA
I HVTN 073 Completed SAAVI DNA-C2 SAAVI MVA-C DNA, Viral Vector - Pox South Africa, USA
I HVTN 086, SAAVI 103 Ongoing SAAVI MVA-C SAAVI DNA-C2 Oligomeric gp140/MF59 Viral Vector - Pox, DNA, Protein South Africa
I HVTN 097 Completed ALVAC-HIV vCP1521 AIDSVAX B/E Viral Vector - Pox, Protein South Africa
Ib HVTN 097 v2.0 Scheduled AIDSVAX B/E Protein South Africa
I/II HVTN 100 Ongoing ALVAC-HIV-C (vCP2438) Bivalent Subtype C gp120/MF59 Viral Vector - Pox, Protein South Africa
I HVTN 101 Withdrawn DNA-HIV-PT123 NYVAC-HIV-PT1 AIDSVAX B/E DNA, Viral Vector - Pox, Protein United Kingdom, South Africa
I/II HVTN 108 Ongoing DNA-HIV-PT123 Bivalent Subtype C gp120/AS01B Bivalent Subtype C gp120/MF59 DNA, Protein, Protein South Africa, USA
I HVTN 111 Ongoing DNA-HIV-PT123 Protein/MF59 vaccine DNA, Protein Zambia, Tanzania, South Africa
I HVTN 116 Ongoing VRC-HIVMAB060-00-AB VRCHIVMAB080-00-AB Passive Immunization, Passive Immunization South Africa, USA
I/II HVTN 120 Ongoing ALVAC-HIV (vCP2438) gp120 Viral Vector - Pox, Protein South Africa, Tanzania, Zambia
II HVTN 204 Closed to follow-up VRC-HIVDNA016-00-VP VRC-HIVADV014-00-VP DNA, Viral Vector - Adeno South Africa, USA
IIb HVTN 503 (Phambili) Terminated MRKAd5 HIV-1 gag/pol/nef Viral Vector - Adeno South Africa
0 HVTN 701 Scheduled South Africa
III HVTN 702 Ongoing ALVAC-HIV-C (vCP2438) Bivalent Subtype C gp120/MF59 Viral Vector - Pox, Protein South Africa
IIb HVTN 703 AMP Ongoing VRC-HIVMAB060-00-AB Passive Immunization South Africa, Kenya, Malawi, Mozambique, Tanzania, Botswana
IIb HVTN 705 Scheduled Ad26.Mos4.HIV gp140 C Viral Vector - Adeno, Protein South Africa
I IAVI 011 Completed MVA.HIVA Viral Vector - Pox South Africa, Switzerland, United Kingdom
II IAVI A002 Completed tgAAC09 Viral Vector - Adeno-associated Virus South Africa, Uganda, Zambia
I IAVI B003 Completed Ad26.EnvA-01 Ad35-ENV Viral Vector - Adeno, Viral Vector - Adeno Kenya, Rwanda, South Africa, USA
I IMPAACT P1112 Ongoing VRC-HIVMAB060-00-AB Passive Immunization USA, Puerto Rico, South Africa