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THE IAVI NEUTRALIZING ANTIBODY CENTER AT THE SCRIPPS RESEARCH INSTITUTE

Antibody-red-webThe Scripps Research Institute/IAVIScientists at IAVI’s Neutralizing Antibody Center are dedicated to unlocking the secrets of protective human immune responses to HIV and harnessing them to create an AIDS vaccine. The Research Center is located at The Scripps Research Institute (TSRI) in California and serves as the hub of IAVI’s Neutralizing Antibody Consortium (NAC), a global network of researchers working collaboratively to design HIV vaccine candidates. Virologists, structural and computational biologists, and immunologists work together in state-of-the-art laboratories to determine how to elicit neutralizing antibodies to block HIV infection—an effort led by NAC Scientific Director Dr. Dennis Burton.

Scientists at the Center are unraveling the secrets of neutralizing antibodies against HIV—which are found in a subset of HIV infected individuals—and applying that knowledge to devise vaccine candidates for clinical evaluation that might elicit similar antibodies. Solving this formidable scientific problem is one of IAVI’s highest priorities, and it requires the application of advanced technology, the expertise of leading scientists and dedicated funding. Recent breakthroughs have illuminated a path forward in this endeavor, generating optimism that the neutralizing antibody problem can be solved. Scientists at IAVI, Scripps and other affiliated institutions have made landmark discoveries to advance the effort, particularly through their discovery and analysis of potent antibodies that neutralize almost all circulating HIV strains. 

Research unlocking this aspect of the human immune system’s fight against HIV continues and is certain to yield novel approaches to the design of vaccines against HIV and other infectious agents. This work would not be possible without the financial support of dedicated donors and individuals who are deeply committed to IAVI's mission.