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IAVI Report, Vol. 14 (4), July-August, 2010

Published: July-August 2010

In this issue:

  • Vaccines to Antibodies: Grow Up!: All of the HIV-specific antibodies identified so far have accumulated multiple mutations—some of which are required for them to bind to and neutralize HIV—through a process called affinity maturation. Researchers are now beginning to grapple with what this means for vaccine design.
  • Microbicides Finally Gel, Securing Spotlight at the International AIDS Conference: The efficacy of a microbicide candidate was the definitive bright spot at this year’s conference, while the lingering economic slowdown and its impact on HIV/AIDS funding were dark clouds on the horizon.
  • A Systems Approach to Understanding Vaccines: Researchers are starting to apply the tools of systems biology to better understand human immune responses to vaccination, including HIV vaccine candidates.
  • Research Briefs: 3-D Structure of Dendritic Cell-T Cell Virological Synapses Revealed.
  • Vaccine Briefs: First US National AIDS Strategy Aims to Cut New Infections and Optimize Care; Vaccine Candidate Targeting Dendritic Cells Enters Clinical Trial.

2009 Annual Progress Report

Published: 2010

This report details key IAVI activities in 2009 related to research and development, policy and advocacy, and country-level and global programs on our mission to develop a safe, effective accessible, preventive HIV vaccine for all.

Sankalp August 2010 Volume 9

Published: August 2010

A Newsletter on AIDS Vaccine Research in India

Progress on the path toward an AIDS vaccine

Published: July 2010

This info sheet examines encouraging progress researchers have made in recent months toward the development of an HIV vaccine. These scientific advances include a clinical trial in Thailand demonstrating for the first time that a vaccine can prevent HIV infection in humans, the discovery of two new antibodies against HIV, and promising research showing that replicating vectors could provoke more effective immune responses against HIV than have so far been observed.

From Research Volunteers to the Global Political Community: Building on Preparedness Efforts for the Development of an AIDS Vaccine

Published: 2010

Vaccine preparedness is a comprehensive, partnership-based approach to help countries and communities involved in AIDS vaccine research and to generate support for such efforts in the global community.  This brief describes IAVI’s approach to vaccine preparedness and the core strategies used to meet the challenges of conducting this work in low-income countries hit hardest by HIV.

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