Accelerating progress toward an AIDS vaccine depends on management and scale of effort in addition to resources and science. This study looks to the history of vaccine development and other large science and engineering initiatives for lessons that might inform current debates about the organization of AIDS vaccine R&D.
The study examines the roles of the public and private sectors in various stages of HIV vaccine development in light of each sector's contributions to vaccine R&D since 1945 and the major institutional and regulatory changes that have occurred in recent decades. The paper also draws on an analysis of the Manhattan Project and the War on Cancer to weigh the benefits and risks of stronger central direction of AIDS vaccine R&D. The paper highlights the complementary roles that public and private financing and management, and "big" and "small" science, can play in stimulating progress toward an AIDS vaccine.
To learn more, click on the following link: R&D Models: Lessons from Vaccine History