Chief Medical Officer and Executive Director for IAVI Medical Affairs
Fran has over 10 years experience leading HIV prevention clinical trial programs, both in the U.S. and Africa. Since joining IAVI as a medical director in 2006, Fran has managed planning and implementation for clinical development of IAVI-sponsored vaccine candidates, primarily in Africa, with a special focus on preparing for efficacy trials and understanding the impact of new prevention technologies. She led the design and implementation of two novel oral PrEP trials sponsored by IAVI, which provided the first data on the adherence and acceptability of intermittent PrEP regimens in at-risk African populations. She led the clinical aspects of IAVI’s Protocol G to identify novel neutralizing antibodies from HIV-infected volunteers in twelve countries.
Prior to her work with IAVI, Fran was an Assistant Professor in the Division of Infectious Disease at Emory University School of Medicine. She served as Medical Director of the Emory Vaccine Center’s clinical trials site, where she was principal investigator for eight phase 1 and 2B HIV vaccine and microbicide clinical trials. Fran has hands-on experience caring for patients as an attending physician on the inpatient and outpatient HIV services at Grady Memorial Hospital in Atlanta. In addition to HIV vaccines, Fran’s research focused on development of novel HIV prevention technologies for women. Fran received the first CDC contract to conduct domestic HIV microbicide clinical trials in the U.S. and established a $2.2 million microbicide clinical trial program at Emory. With colleagues, she published the first description of acceptability of intravaginal rings in African female sex workers and led a collaborative program with University of Nairobi to identify a new high incidence sex worker cohort in Nairobi. Fran received her medical degree from the University of California, San Francisco, is board certified in internal medicine and holds a Masters in public health from University of California, Berkeley. Her prior research and field experience in Africa includes HIV-related work in Zambia, Ethiopia, Kenya, Malawi and Zaire.
Fran is available to comment on the following issues:
- IAVI’s clinical development program and overall approach to AIDS vaccine trials
- The international network of IAVI-supported clinical research centers
- Current issues in AIDS vaccine development
- HIV and AIDS-related clinical research
- Epidemiological research on HIV and the immunology of HIV infection
- The participation of developing countries in AIDS vaccine design and development
- The importance of a comprehensive response to the AIDS pandemic
- The challenges of working with socially vulnerable populations