From Research Volunteers to the Global Political Community: Building on Preparedness Efforts for the Development of an AIDS Vaccine

Published: 2010

Vaccine preparedness is a comprehensive, partnership-based approach to help countries and communities involved in AIDS vaccine research and to generate support for such efforts in the global community.  This brief describes IAVI’s approach to vaccine preparedness and the core strategies used to meet the challenges of conducting this work in low-income countries hit hardest by HIV.

Progress on the path toward an AIDS vaccine

Published: July 2010

This info sheet examines encouraging progress researchers have made in recent months toward the development of an HIV vaccine. These scientific advances include a clinical trial in Thailand demonstrating for the first time that a vaccine can prevent HIV infection in humans, the discovery of two new antibodies against HIV, and promising research showing that replicating vectors could provoke more effective immune responses against HIV than have so far been observed.

What You Should Know about AIDS Vaccine Development

Published: July 2010

This pamphlet provides a snap-shot overview of key information on AIDS vaccine development in a convenient format, covering why an AIDS vaccine is needed, why it is possible to develop one, and how you can contribute to reaching the ultimate goal of finding one.

Working for a world without AIDS

Published: 2010

This publication contains an update on the latest progress in research, the work and mission of IAVI, the commitments made by the European Union in support of AIDS vaccine R&D and the crucial role Europe can play in supporting the search for an AIDS vaccine.

Adapting to Realities: Trends in HIV Prevention Research Funding 2000 to 2008 - Vaccines Summary

Published: July 2009

This document summarizes 2008 estimates of public, philanthropic, and commercial investment in research and development (R&D) for AIDS vaccines. These estimates were generated through a collaborative project involving the AIDS Vaccine Advocacy Coalition (AVAC), the Alliance for Microbicide Development (AMD), the International AIDS Vaccine Initiative (IAVI), and the UNAIDS Resource Tracking Unit. More information on the HIV Vaccines and Microbicides Resource Tracking Working Group can be found at http://www.hivresourcetracking.org/ .

AIDS Vaccine Q & A

Published: 2009

This listing of questions and answers provides basic information on vaccines and addresses how an AIDS vaccine would work, how AIDS vaccines are tested and why scientists believe the development of an AIDS vaccine is possible .

Clinical Guidance: Essential Approaches for the Conduct of IAVI Clinical Research

Published: 2009

This document outlines essential processes and practices required to conduct IAVI-sponsored research, based on the specific research and sociocultural context and the needs of the research team, study volunteers, and community. This guidance applies to
clinical trials and to observational and behavioural research studies to ensure that the research itself and associated capacity building efforts and service delivery activities meet high ethical and quality standards.

IAVI Report, Vol. 13 (1), Jan.-Feb. 2009

Published: January-February 2009

In this issue:

• Canvassing CROI: The successes of ARV therapy and promising results with new HIV prevention strategies stoke excitement at recent scientific meeting
• In With the New...: The AIDS vaccine field considers ways to encourage innovation and recruit new minds to the effort
• Perspective: Challenges Facing Young Investigators: Three junior researchers describe the hurdles to succeeding in the AIDS vaccine field
• It Eradicated Smallpox, But How?: Researchers are finally collecting clues about the life-long protection afforded by the smallpox vaccine, the gold standard of vaccines
• Research Briefs: Researchers Employ Systems Biology Approach to Predict Adaptive Immune Response to Yellow Fever Vaccine Elite Controllers Found to Have More Lethal CD8+ T Cells
• Vaccine Briefs: Four New AIDS Vaccine Trials Launched in Recent Weeks

IAVI Report, Vol. 13 (2), Mar.-Apr. 2009

Published: March-April 2009

In this issue:

• Editor's Letter
• Capsules from Keystone: A broad collection of updates at this year’s joint symposia served to inform the development of future AIDS vaccine candidates
• A Living History of AIDS Vaccine Research: Anthony Fauci talks about the quest for an AIDS vaccine in the first chapter of this special series
• Vaccine Briefs: The Collaboration for AIDS Vaccine Discovery reports progress; The Kenya AIDS Vaccine Initiative marks 10-year anniversary
• Research Briefs: CMV-based vaccine candidate protects macaques from systemic infection; Microbicide inhibits innate immune response; Researchers catch HIV on film

Innovative Financing Mechanisms to Advance Global Health

Published: June 2009

This policy brief reviews recent innovations in health financing and new options under consideration to address current funding gaps that deter efforts to improve health in resource-limited countries.  Note: Revised version posted on July 15, 2009.